Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya.

@article{Deng2004FluorometaboliteBA,
  title={Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya.},
  author={Hai Deng and David O'Hagan and Christoph Schaffrath},
  journal={Natural product reports},
  year={2004},
  volume={21 6},
  pages={773-84}
}
This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosyntheses in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C-F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to… CONTINUE READING

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