Fluorofenidone attenuates diabetic nephropathy and kidney fibrosis in db/db mice.


BACKGROUND/AIMS Fluorofenidone [1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone, AKF-PD], a novel pyridone agent, showed potent antifibrotic properties. The aim of the present study was to investigate the effects of AKF-PD on diabetic nephropathy and kidney fibrosis, and to obtain an insight into its mechanisms of action. METHODS We administered AKF-PD to… (More)
DOI: 10.1159/000329419


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