Fluorocytosine causes uncoupled dissipation of the proton gradient and behaves as an imperfect substrate of the yeast cytosine permease.

Abstract

At pH 5-6 ATP-depleted washed cell preparations of strain NC233-10b[pII4-9], in which the cytosine permease was overexpressed, absorbed cytosine, hypoxanthine or fluorocytosine stoichiometrically with, respectively, about 1, 1.4 and 5 proton equivalents. The cellular pH fell proportionately. The membrane depolarization caused by each compound was assayed in… (More)

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Cite this paper

@article{Hopkins1992FluorocytosineCU, title={Fluorocytosine causes uncoupled dissipation of the proton gradient and behaves as an imperfect substrate of the yeast cytosine permease.}, author={Peter M. A. Hopkins and R. Shaw and Leyla Açik and Seb Oliver and Alison Eddy}, journal={Yeast}, year={1992}, volume={8 12}, pages={1053-64} }