Fluorocitrate-mediated astroglial dysfunction causes seizures.

@article{Willoughby2003FluorocitratemediatedAD,
  title={Fluorocitrate-mediated astroglial dysfunction causes seizures.},
  author={John O. Willoughby and Lorraine Mackenzie and Marita Broberg and Anna E Thoren and Andrei V. Medvedev and Neil R Sims and Michael Nilsson},
  journal={Journal of neuroscience research},
  year={2003},
  volume={74 1},
  pages={
          160-6
        }
}
  • John O. Willoughby, Lorraine Mackenzie, +4 authors Michael Nilsson
  • Published in
    Journal of neuroscience…
    2003
  • Biology, Medicine
  • A role for astroglia in epileptogenesis has been hypothesised but is not established. Low doses of fluorocitrate specifically and reversibly disrupt astroglial metabolism by blocking aconitase, an enzyme integral to the tricarboxylic acid cycle. We used cerebral cortex injections of fluorocitrate, at a dose that we demonstrated to inhibit astroglial metabolism selectively, to determine whether astroglial disturbances lead to seizures. Rats were halothane-anesthetized, and 0.8 nmol of sodium… CONTINUE READING

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