Fluorine effects in organocatalysis - asymmetric Brønsted acid assisted Lewis base catalysis for the synthesis of trifluoromethylated heterocycles exploiting the negative hyperconjugation of the CF3-group.

@article{Volla2014FluorineEI,
  title={Fluorine effects in organocatalysis - asymmetric Br{\o}nsted acid assisted Lewis base catalysis for the synthesis of trifluoromethylated heterocycles exploiting the negative hyperconjugation of the CF3-group.},
  author={Chandra M R Volla and Arindam Das and Iuliana Atodiresei and Magnus Rueping},
  journal={Chemical communications},
  year={2014},
  volume={50 58},
  pages={
          7889-92
        }
}
  • Chandra M R Volla, Arindam Das, +1 author Magnus Rueping
  • Published in Chemical communications 2014
  • Chemistry, Medicine
  • An efficient Brønsted acid assisted Lewis base catalysis protocol for the synthesis of enantiomerically pure trifluoromethylated dihydropyridazines starting from readily available hydrazones and α,β-unsaturated aldehydes has been developed. The reaction exhibits high tolerance towards many functional groups and is applicable to various aliphatic, aromatic and hetero-aromatic α,β-unsaturated aldehydes, and provides the products in good yields and with excellent enantioselectivities. 

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