Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway.

  title={Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway.},
  author={Jonathan Dickerhoff and Klaus Weisz},
  journal={Chembiochem : a European journal of chemical biology},
  volume={19 9},
A (3+1)-hybrid-type G-quadruplex was substituted within its central tetrad by a single 2'-fluoro-modified guanosine. Driven by the anti-favoring nucleoside analogue, a novel quadruplex fold with inversion of a single G-tract and conversion of a propeller loop into a lateral loop emerges. In addition, scalar couplings across hydrogen bonds demonstrate the… CONTINUE READING