Fluorine-Containing Block and Gradient Copoly(2-oxazoline)s Based on 2-(3,3,3-Trifluoropropyl)-2-oxazoline: A Quest for the Optimal Self-Assembled Structure for 19F Imaging.

@article{Kaberov2021FluorineContainingBA,
  title={Fluorine-Containing Block and Gradient Copoly(2-oxazoline)s Based on 2-(3,3,3-Trifluoropropyl)-2-oxazoline: A Quest for the Optimal Self-Assembled Structure for 19F Imaging.},
  author={Leonid I Kaberov and Zhansaya Kaberova and Anastasiia Murmiliuk and Jiř{\'i} Trousil and Ondřej Sedl{\'a}{\vc}ek and Rafał Konefał and Alexander Zhigunov and Ewa Pavlova and Martina Vit and Daniel Jir{\'a}k and Richard Hoogenboom and Sergey K. Filippov},
  journal={Biomacromolecules},
  year={2021}
}
The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous fluorine atoms in the body. In this work, we present a comprehensive study of the influence of the amphiphilic polymer structure and composition on its applicability as contrast agents in 19F MRI. Three series of novel fluorine-containing poly(2-oxazoline) copolymers and terpolymers, hydrophilic-fluorophilic, hydrophilic-lipophilic-fluorophilic…