Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[18F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography.

@article{Jahan2012Fluorine18LO,
  title={Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[18F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography.},
  author={M. Jahan and S. Nag and R. Krasikova and U. Weber and A. Muhs and A. Pfeifer and C. Spenger and D. Willbold and B. Guly{\'a}s and C. Halldin},
  journal={Nuclear medicine and biology},
  year={2012},
  volume={39 3},
  pages={
          315-23
        }
}
  • M. Jahan, S. Nag, +7 authors C. Halldin
  • Published 2012
  • Chemistry, Medicine
  • Nuclear medicine and biology
  • INTRODUCTION β-Amyloid (Aβ) plaques and neurofibrillary tangles are the main characteristics of Alzheimer's disease (AD). Positron emission tomography (PET), a high-resolution, sensitive, and noninvasive imaging technique, has been widely utilized in visualizing the localization of plaques and tangles and thereby distinguishing between AD and healthy controls. A small 12-mer D-enantiomeric peptide (amino acid sequence=QSHYRHISPAQV), denoted as D1, has high binding affinity to Aβ in vitro in the… CONTINUE READING
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    References

    SHOWING 1-10 OF 38 REFERENCES
    In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18)
    • 544
    • PDF
    In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET.
    • N. P. Verhoeff, A. Wilson, +6 authors S. Houle
    • Medicine
    • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
    • 2004
    • 325
    Detection of amyloid in Alzheimer’s disease with positron emission tomography using [11C]AZD2184
    • 77
    • PDF
    Selection of D‐Amino‐Acid Peptides That Bind to Alzheimer's Disease Amyloid Peptide Aβ1–42 by Mirror Image Phage Display
    • 101
    Brain radioligands--state of the art and new trends.
    • C. Halldin, B. Gulyás, O. Langer, L. Farde
    • Medicine
    • The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology
    • 2001
    • 112
    Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.
    • K. Shoghi-Jadid, G. Small, +8 authors J. Barrio
    • Chemistry, Medicine
    • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
    • 2002
    • 689