Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B.

@article{Yoshida2004FluorinatedPP,
  title={Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B.},
  author={Shinichi Yoshida and Thomas C. Rosen and Oliver Meyer and Milton J. Sloan and Song Ye and G{\"u}nter Haufe and Kenneth Lee Kirk},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 10},
  pages={
          2645-52
        }
}
Fluorinated phenylcyclopropylamines and alkylamines were examined as inhibitors of recombinant human liver monoamine oxidase A (MAO A) and B (MAO B). For a series of trans- and cis-2-fluoro-2-phenylcyclopropylamine analogues, the presence of fluorine attached to a cyclopropane ring was found to result in an increase in inhibitory activity towards both MAO A and B. In addition, p-substitution of electron-withdrawing groups such as Cl and F in the aromatic ring of the trans-isomers increased the… CONTINUE READING
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