Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity.

Abstract

Liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. The ability of LXRs to integrate metabolic and inflammation signalling makes them attractive targets for intervention in human metabolic diseases. Several oxidized metabolites of cholesterol (oxysterols) are endogenous LXR ligands, that… (More)
DOI: 10.1016/j.jsbmb.2016.07.001

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