Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.

@article{Moumn2010FluorinatedDA,
  title={Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.},
  author={Roba Moumn{\'e} and Morgane Pasco and E. Prost and Thomas Lecourt and Laurent Micouin and Carine Tisn{\'e}},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 38},
  pages={13111-3}
}
The supramolecular chiral recognition between rac-2a and several structured RNA leads to a distinct (19)F NMR signal splitting. The (19)F NMR analysis of the diastereomeric pairs formed upon binding of this racemic probe delivers a topological footprint of the RNA. This phenomenon can be exploited to investigate dynamic events involving structural equilibria, as demonstrated in a melting experiment. This work provides a proof of concept that small fluorinated moderate binders can act as… CONTINUE READING