Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.

@article{Zhang2013FluorinatedNR,
  title={Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.},
  author={W. Zhang and Vitaliy M Sviripa and X. Chen and Jiandang Shi and Tianxin Yu and A. Hamza and N. Ward and Liliia M. Kril and C. V. Vander Kooi and C. Zhan and B. Evers and D. Watt and Chunming Liu},
  journal={ACS chemical biology},
  year={2013},
  volume={8 4},
  pages={
          796-803
        }
}
Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. MAT2A is up-regulated in many cancers, including liver cancer and colorectal cancer (CRC) and is a potentially important drug target. We developed a family of fluorinated N,N-dialkylaminostilbene agents, called FIDAS agents, that inhibit the proliferation of CRC cells in vitro and in vivo. Using a biotinylated FIDAS analogue… Expand
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