Fluorimetric liquid chromatographic analysis of amantadine in urine and pharmaceutical formulation.

Abstract

A simple and sensitive liquid chromatographic method is described for the analysis of amantadine and memantine. The method is based on the derivatization of amantadine and memantine extracted from alkalified samples with (2-naphthoxy)acetyl chloride at mild conditions. The resulting derivatives were analyzed by isocratic HPLC with a fluorimetric detector… (More)

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Cite this paper

@article{Duh2005FluorimetricLC, title={Fluorimetric liquid chromatographic analysis of amantadine in urine and pharmaceutical formulation.}, author={Tsai-Hui Duh and Hsin-lung Wu and Chi-Wen Pan and Hwang-Shang Kou}, journal={Journal of chromatography. A}, year={2005}, volume={1088 1-2}, pages={175-81} }