Fluoride mediates apoptosis in osteosarcoma UMR 106 and its cytotoxicity depends on the pH

@article{Hirano1997FluorideMA,
  title={Fluoride mediates apoptosis in osteosarcoma UMR 106 and its cytotoxicity depends on the pH},
  author={Seishiro Hirano and Mitsuru Ando},
  journal={Archives of Toxicology},
  year={1997},
  volume={72},
  pages={52-58}
}
 Although an excess intake of fluoride has been reported to cause skeletal fluorosis, very little is known about the mechanism of adverse effects of fluoride on bone. In the present study cytotoxic effects of fluoride were studied using the osteosarcoma cell line, UMR 106. The DNA ladder formation upon agarose electrophoresis and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining revealed that UMR 106 underwent apoptosis following exposure to 5 mM… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

olecular mechanisms of fluoride toxicity

livier Barbiera, Laura Arreola-Mendozab, Luz María Del Razoa
2010

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Lange's handbook of chemistry

JA Dean
1973
View 2 Excerpts
Highly Influenced

Developmental toxicity evaluation of sodium fluoride administered to rats and rabbits in drinking water.

Fundamental and applied toxicology : official journal of the Society of Toxicology • 1996
View 1 Excerpt

Similar Papers

Loading similar papers…