• Chemistry, Medicine
  • Published in Journal de biologie buccale 1992

Fluoride inhibition of SCN- and Cl-peroxidase activities in whole saliva and of recombinant myeloperoxidase. Influence of pH and hydrogen peroxide concentration.

@article{Abbeele1992FluorideIO,
  title={Fluoride inhibition of SCN- and Cl-peroxidase activities in whole saliva and of recombinant myeloperoxidase. Influence of pH and hydrogen peroxide concentration.},
  author={Annick Van den Abbeele and Michel Pourtois and Pierrette Courtois},
  journal={Journal de biologie buccale},
  year={1992},
  volume={20 4},
  pages={
          219-24
        }
}
Fluoride (F-) inhibition of peroxidase activity in whole saliva and of recombinant human myeloperoxidase was investigated using thiocyanate (SCN-) and chloride (Cl-) as substrates. At pH 5.5, SCN(-)-linked activity in whole saliva reduced to < 40% of its initial value at F- concentration of 20 mM, while Cl- linked activity was maintained at 90% of its initial value for the same F-concentration. Based on this Cl(-)-linked activity, the contribution of natural MP to the SCN(-)-linked activity in… CONTINUE READING

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