Fluoride effects on bone formation and mineralization are influenced by genetics.

  title={Fluoride effects on bone formation and mineralization are influenced by genetics.},
  author={Maryline Mousny and Sidney Omelon and Lisa M. Wise and Eric T. Everett and Mircea Dumitriu and D P Holmyard and Xavier Banse and J. P. Devogelaer and Marc D. Grynpas},
  volume={43 6},
INTRODUCTION A variation in bone response to fluoride (F(-)) exposure has been attributed to genetic factors. Increasing fluoride doses (0 ppm, 25 ppm, 50 ppm, 100 ppm) for three inbred mouse strains with different susceptibilities to developing dental enamel fluorosis (A/J, a "susceptible" strain; SWR/J, an "intermediate" strain; 129P3/J, a "resistant" strain) had different effects on their cortical and trabecular bone mechanical properties. In this paper, the structural and material… CONTINUE READING
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