Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

@article{Bigay1987FluorideCO,
  title={Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.},
  author={Jo{\"e}lle Bigay and Philippe Deterre and Corinne Pfister and Marc Chabre},
  journal={The EMBO journal},
  year={1987},
  volume={6 10},
  pages={2907-13}
}
Fluoride activation of G proteins requires the presence of aluminium or beryllium and it has been suggested that AIF4- acts as an analogue of the gamma-phosphate of GTP in the nucleotide site. We have investigated the action of AIF4- or of BeF3- on transducin (T), the G protein of the retinal rods, either indirectly through the activation of cGMP phosphodiesterase, or more directly through their effects on the conformation of transducin itself. In the presence of AIF4- or BeF3-, purified T… CONTINUE READING