Fluoride and organic weak acids as modulators of microbial physiology.

  title={Fluoride and organic weak acids as modulators of microbial physiology.},
  author={Robert E. Marquis and Sarah A Clock and Marilaine Mota-Meira},
  journal={FEMS microbiology reviews},
  volume={26 5},
Fluoride is widely used as an anticaries agent in drinking water and a variety of other vehicles. This use has resulted in major health benefits. However, there are still open questions regarding the mechanisms of anticaries action and the importance of antimicrobial effects in caries reduction. Fluoride acts in multiple ways to affect the metabolism of cariogenic and other bacteria in the mouth. F(-)/HF can bind directly to many enzymes, for example, heme-containing enzymes or other… CONTINUE READING


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