Fluorescent markers for studying phagosome-lysosome fusion.

  title={Fluorescent markers for studying phagosome-lysosome fusion.},
  author={Mayer B. Goren and Charles L. Swendsen and J A Fiscus and Cindy K Miranti},
  journal={Journal of leukocyte biology},
  volume={36 3},
Lysosomotropic fluorescent aminoacridines such as acridine orange and quinacrine have achieved prominence as markers for studying lysosome-phagosomes fusion, especially in macrophages. Experiments described demonstrate that because the aminoacridines traverse biological membranes with facility, they diffuse throughout the system, and ultimately accumulate intra- or extracellularly where they are most efficiently bound. Their presence or absence in phagosomes is therefore not unequivocally… CONTINUE READING

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