Fluorescent-ligand-mediated screening of G-quadruplex structures using a DNA microarray.

  title={Fluorescent-ligand-mediated screening of G-quadruplex structures using a DNA microarray.},
  author={Keisuke Iida and Takahiro Nakamura and Wataru Yoshida and Masayuki Tera and Kazuhiko Nakabayashi and Kenichiro Hata and Kazunori Ikebukuro and Kazuo Nagasawa},
  journal={Angewandte Chemie},
  volume={52 46},
Cell-cycle-synchronized DNA replication and cellular-environment-dependent gene expression are mainly controlled by proteins and DNAs with higher-order structures, such as G-quadruplexes (G4s). G4s are non-canonical nucleic acid structures that are formed by the stacking of planar Gquartets, and they are in equilibrium with random coils. These structures were originally found in telomeric DNA at the ends of chromosomes. The formation of telomeric G4s induces dysfunctions of telomeres in cancer… CONTINUE READING
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For the monomer of telomestatin derivatives , see : a ) M . Tera , Y . Sohtome

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2 Excerpts

Distributions of the fluorescence intensities of all probes are shown in the Supporting Information

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