Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.

@article{Daly2010FluorescentLB,
  title={Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.},
  author={Craig Daly and Ruth A. Ross and Jamie Whyte and Christopher M. Henstridge and Andrew J. Irving and John C. McGrath},
  journal={British journal of pharmacology},
  year={2010},
  volume={159 4},
  pages={787-96}
}
BACKGROUND AND PURPOSE Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors are located in the same cells. We have now investigated the distribution of alpha-adrenoceptors, beta-adrenoceptors and cannabinoid-like (GPR55) receptors in the mouse arteries. EXPERIMENTAL APPROACH Fluorescence intensity from vascular tissue incubated with fluorescent ligands (alpha(1)-adrenoceptor ligand, BODIPY-FL-prazosin, QAPB… CONTINUE READING