Fluorescent cellular indicators are extruded by the multidrug resistance protein.

@article{Homolya1993FluorescentCI,
  title={Fluorescent cellular indicators are extruded by the multidrug resistance protein.},
  author={L{\'a}szl{\'o} Homolya and Zsolt Holl{\'o} and Ursula A. Germann and Ira Pastan and Michael M. Gottesman and Bal{\'a}zs Sarkadi},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 29},
  pages={21493-6}
}
In this report we show that NIH-3T3 mouse fibroblasts stably expressing the human multidrug transporter (MDR1 or P-glycoprotein), in contrast to the control NIH-3T3 cells, actively extrude the hydrophobic acetoxymethyl ester (AM) derivatives used for cellular loading of various fluorescent calcium and pH indicators. This dye extrusion is blocked by competing substrates and inhibitors of the multidrug transporters, e.g. by verapamil, vincristine, sodium orthovanadate, oligomycin, and a… CONTINUE READING
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