Fluorescent brightener inhibits apoptosis in baculovirus-infected gypsy moth larval midgut cells in vitro

@inproceedings{Dougherty2006FluorescentBI,
  title={Fluorescent brightener inhibits apoptosis in baculovirus-infected gypsy moth larval midgut cells in vitro},
  author={Edward M. Dougherty and Neelam Narang and Marcia J. Loeb and Dwight Earl Lynn and Martin M. Shapiro},
  year={2006}
}
Fluorescent brighteners significantly lower the LC50 and LT50 in a variety of nucleopolyhedrovirus /insect host systems. In larvae of the gypsy moth, Lymantria dispar (L.), a European NPV strain of virus (LdMNPV) does not normally replicate in the midgut, but addition of a fluorescent brightener (Calcofluor M2R) to the virus suspension results in productive infections. In the current study, we show that LdMNPV also does not replicate in a larval midgut primary cell culture system unless a… CONTINUE READING

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