Fluorescent bacterial magnetic nanoparticles as bimodal contrast agents.

  title={Fluorescent bacterial magnetic nanoparticles as bimodal contrast agents.},
  author={Marcus-Ren{\'e} Lisy and Annegret Hartung and Claus Lang and Dirk Schueler and Walter Richter and J{\"u}rgen R. Reichenbach and Werner A. Kaiser and I. Hilger},
  journal={Investigative radiology},
  volume={42 4},
OBJECTIVES The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS Bacterial magnetic nanoparticles (magnetosomes, particle diameter: 42 nm) were harvested from Magnetospirillum gryphiswaldense and characterized by using MRI. After covalent coupling to the fluorescent… CONTINUE READING