Fluorescence study on the conformation of a cyclic enkephalin analog in aqueous solution.

@article{Schiller1983FluorescenceSO,
  title={Fluorescence study on the conformation of a cyclic enkephalin analog in aqueous solution.},
  author={Peter W. Schiller},
  journal={Biochemical and biophysical research communications},
  year={1983},
  volume={114 1},
  pages={268-74}
}
Conformational parameters of the potent cyclic enkephalin analogs [D-Cys2, D-Cys5]enkephalinamide and [D-Cys2, Trp4, D-Cys5]enkephalinamide were determined by steady-state fluorescence measurements. The very low tyrosine fluorescence quantum yield observed with [D-Cys2, D-Cys5]enkephalinamide reflects a close intramolecular interaction between the phenol ring of Tyr1 and the disulfide bridge. Evaluation of resonance energy transfer between Tyr1 (donor) and Trp4 (acceptor) of [D-Cys2, Trp4, D… CONTINUE READING