Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells.

@article{Sahu2008FluorescenceSO,
  title={Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells.},
  author={Abhishek Sahu and Naresh Kasoju and Utpal Jyoti Bora},
  journal={Biomacromolecules},
  year={2008},
  volume={9 10},
  pages={2905-12}
}
In milk caseins exists a natural nanostructure, which can be exploited as a carrier of hydrophobic drugs. Here we investigated the complex formation of curcumin with bovine casein micelles (CMs) and its use as a vehicle for drug delivery to cancer cells. DLS studies of the CM suspension that was stable in buffer solution (pH 7.4) showed an average size distribution of <200 nm. SEM and AFM studies showed that the particles were roughly spherical in shape. Steady-state fluorescence spectroscopy… CONTINUE READING