Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway.

@article{Narayanan2005FluorescenceSS,
  title={Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway.},
  author={Vijaya Narayanan and Yuanjian Guo and Suzanne F. Scarlata},
  journal={Biochemistry},
  year={2005},
  volume={44 2},
  pages={462-70}
}
Alpha-synuclein plays a key role in the pathogenesis of many neurodegenerative diseases. To date, its cellular role has yet to be determined, although it has been proposed to be connected to calcium and G protein-mediated dopamine signaling. Alpha-synuclein is known to bind strongly to model membrane surfaces where it may interact with other membrane-associated proteins. Here, we find that the membrane association of alpha-synuclein is enhanced by the presence of phosphatidylinositol 4,5… CONTINUE READING
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