Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase

@article{Gorro2007FluorescenceRE,
  title={Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase},
  author={Silvia S Gorr{\~a}o and Jefferson Pessoa Hemerly and Aurelio Resende Lima and Robson Melo and Luiz Juliano},
  journal={Peptides},
  year={2007},
  volume={28},
  pages={2146-2154}
}
Prolyl oligopeptidase (POP, EC 3.4.21.26) is a member of a family of serine peptidases with post-proline cleaving activity towards peptides. It is located in the cytosol in active form but without hydrolytic activity on proteins or peptides higher than 30 amino acids. Its function is not well defined, but it is involved in central nervous system disorders. Here, we studied the substrate specificity of wild type POP (POPwt) and its C255T variant lacking the non-catalytic Cys(255). This residue… CONTINUE READING