Fluorescence quenching of dipyridamole associated to peroxyl radical scavenging: a versatile probe to measure the chain breaking antioxidant activity of biomolecules.

@article{Iuliano2000FluorescenceQO,
  title={Fluorescence quenching of dipyridamole associated to peroxyl radical scavenging: a versatile probe to measure the chain breaking antioxidant activity of biomolecules.},
  author={Luigi Iuliano and Cristina Piccheri and I Coppola and Domenico Pratic{\`o} and Fausta Micheletta and Francesco Violi},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1474 2},
  pages={177-82}
}
Dypiridamole is a highly efficient chain breaking antioxidant (Iuliano et al., Free Radic. Biol. Med. 18 (1995) 239-247) with an aromatic ring system responsible for an intense absorption band in the 400-480-nm region and for an intense fluorescence. Dipyridamole fluorescence is quantitatively quenched upon reaction with peroxyl radicals. In the presence of a flux of peroxyl radicals generated by thermal dissociation of azo-initiators, dipyridamole fluorescence decays linearly, showing a first… CONTINUE READING
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