Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements.

@article{Madrigal2006FluorescenceIS,
  title={Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements.},
  author={Irene Madrigal and Ana Carri{\'o} and C{\'a}ndida G{\'o}mez and Mar{\'i}a Rozman and Jordi Esteve and Benet Nomdedeu and El{\'i}as Campo and Dolors Costa},
  journal={Cancer genetics and cytogenetics},
  year={2006},
  volume={170 2},
  pages={115-20}
}
Chromosomal rearrangements involving 3q26 are a recurrent aberration in malignant myeloid disorders. Several of these rearrangements involve the EVI1 oncogene or its surrounding sequences and are associated with a poor prognosis. Fluorescence in situ hybridization (FISH) studies using bacterial artificial chromosome (BAC) clones were conducted to determine whether the EVI1 locus was rearranged in nine patients with hematological malignancies carrying 3q abnormalities. A dual-color probe was… CONTINUE READING