Fluorescence in situ hybridization on 3D cultures of tumor cells.

  title={Fluorescence in situ hybridization on 3D cultures of tumor cells.},
  author={Karen J. Meaburn},
  journal={Methods in molecular biology},
Genomes are spatially highly organized within interphase nuclei. Spatial genome organization is increasingly linked to genome function. Fluorescence in situ hybridization (FISH) allows the visualization of specific regions of the genome for spatial mapping. While most gene localization studies have been performed on cultured cells, genome organization is likely to be different in the context of tissues. Three-dimensional (3D) culture model systems provide a powerful tool to study the… CONTINUE READING

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