Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.

@article{Kobayashi1994FluorescenceIS,
  title={Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.},
  author={Hirofumi Kobayashi and Kate T. Montgomery and Stefan K Bohlander and Chaker N. Adra and Boon Leong Lim and Raju S. Kucherlapati and Helen Donis-Keller and Matthew S. Holt and Michelle M Le Beau and J D Rowley},
  journal={Blood},
  year={1994},
  volume={84 10},
  pages={3473-82}
}
Translocations and deletions of the short arm of chromosome 12 [t(12p) and del(12p)] are common recurring abnormalities in a broad spectrum of hematologic malignant diseases. We studied 20 patients and one cell line whose cells contained 12p13 translocations and/or 12p deletions using fluorescence in situ hybridization (FISH) with phage, plasmid, and cosmid probes that we previously mapped and ordered on 12p12-13. FISH analysis showed that the 12p13 translocation breakpoints were clustered… CONTINUE READING

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Rearrangements involving chromosome band 1 lq 23 in acute leukemia

  • JD Rowley
  • Semin Cancer Biol
  • 1994

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