Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms

  title={Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms},
  author={Joshua Weaver and Erinn Downs-Kelly and John R. Goldblum and Sondra L Turner and Sucheta S Kulkarni and Raymond R. Tubbs and Brian P. Rubin and Marek Skacel},
  journal={Modern Pathology},
Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas, respectively. Cytogenetics in these tumors has identified ring and giant chromosomes composed of 12q13-15 amplicons including the MDM2 gene. Identifying MDM2 amplification by fluorescence in situ hybridization may prove an adjunctive tool in the diagnosis of lipomatous neoplasms. Dual color fluorescence in situ… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 138 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 81 extracted citations

Liposarcoma masquerading as an inflammatory pseudotumor: a case report

Journal of medical case reports • 2016
View 11 Excerpts
Highly Influenced

Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics?

Journal of Cancer Research and Clinical Oncology • 2013
View 3 Excerpts
Highly Influenced

Molecular Pathology of Sarcoma.

Surgical pathology clinics • 2012
View 5 Excerpts
Highly Influenced

Advances in the targeted therapy of liposarcoma

OncoTargets and therapy • 2015
View 4 Excerpts
Highly Influenced

Intraperitoneal dedifferentiated liposarcoma showing MDM2 amplification: case report

World journal of surgical oncology • 2013
View 10 Excerpts
Highly Influenced

138 Citations

Citations per Year
Semantic Scholar estimates that this publication has 138 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 25 references

Assessment of MDM2 amplification using fluorescence in situ hybridization on paraffin embedded tissues discriminates atypical lipomatous tumors from lipomas

EK Jacob, M Erickson-Johnson, X Wang
Mod Pathol 2006;19:13A • 2006

soft tissue from malignant melanoma

MB Binh, X Sastre-Garau, L Guillou
Mod Pathol 2005;18:1585–1590 • 2005