Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.

  title={Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.},
  author={James A. Raleigh and G. G. Miller and Allan Franko and Cameron J. Koch and Alfred F Fuciarelli and Deirdre A. Kelly},
  journal={British Journal of Cancer},
  pages={395 - 400}
Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue. 

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2 - Hydroxylaminoimidazolesunstable intermediates in the reduction of 2nitroimidazoles

  • A. M. RAUTH
  • Biochem . Pharmacol .
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