Fluorescence imaging of single-molecule retention trajectories in reversed-phase chromatographic particles.

@article{Cooper2013FluorescenceIO,
  title={Fluorescence imaging of single-molecule retention trajectories in reversed-phase chromatographic particles.},
  author={Justin T Cooper and Eric M Peterson and Joel M Harris},
  journal={Analytical chemistry},
  year={2013},
  volume={85 19},
  pages={
          9363-70
        }
}
Due to its high specific surface area and chemical stability, porous silica is used as a support structure in numerous applications, including heterogeneous catalysis, biomolecule immobilization, sensors, and liquid chromatography. Reversed-phase liquid chromatography (RPLC), which uses porous silica support particles, has become an indispensable separations tool in quality control, pharmaceutics, and environmental analysis requiring identification of compounds in mixtures. For complex samples… CONTINUE READING