Fluorescence-expressing viruses allow rapid identification and separation of rare tumor cells in spiked samples of human whole blood.

@article{Fong2009FluorescenceexpressingVA,
  title={Fluorescence-expressing viruses allow rapid identification and separation of rare tumor cells in spiked samples of human whole blood.},
  author={Sandra M B Fong and Melissa Lee and Prasad S Adusumilli and Kaitlyn Jane Kelly},
  journal={Surgery},
  year={2009},
  volume={146 3},
  pages={498-505}
}
BACKGROUND Finding and isolating rare tumor cells in blood allows for diagnosis of disseminated cancer and for molecular profiling to direct the choice of biologic therapy. We explored whether the candidate gene therapy virus NV1066-designed to specifically infect cancer cells and express green fluorescence protein (GFP)-can be used for rapid infection, identification, and isolation of rare circulating tumor cells (CTC) in human whole blood. METHODS Mixtures of human cancer cell lines and… CONTINUE READING
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