Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.

@article{Bedwell1992FluorescenceDA,
  title={Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.},
  author={Joshua Bedwell and Alexander J. Macrobert and D. Phillips and Stephen G. Bown},
  journal={British Journal of Cancer},
  year={1992},
  volume={65},
  pages={818 - 824}
}
Aminolaevulinic acid (ALA) is the first committed step in haem synthesis. In the presence of excess ALA the natural regulatory feedback system is disrupted allowing accumulation of protoporphyrin IX (PP IX) the last intermediate product before haem, and an effective sensitiser. This method of endogenous photosensitisation of cells has been exploited for photodynamic therapy (PDT). We have studied the fluorescence distribution and biological effect of induced PP IX in normal and tumour tissue in… CONTINUE READING
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Selective necrosis in experimental colon cancer using photodynamic therapy with phthalocyanine photosensitisation

  • H. BARR, C. J. TRALAU, P. B. BOULOS
  • Gastroenterology
  • 1990

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