Fluorescence characterization of the transcription bubble in elongation complexes of T7 RNA polymerase.

@article{Liu2001FluorescenceCO,
  title={Fluorescence characterization of the transcription bubble in elongation complexes of T7 RNA polymerase.},
  author={Cuihua Liu and Craig T. Martin},
  journal={Journal of molecular biology},
  year={2001},
  volume={308 3},
  pages={465-75}
}
The various kinetic and thermodynamic models for transcription elongation all require an understanding of the nature of the melted bubble which moves with the RNA polymerase active site. Is the general nature of the bubble system-dependent or are there common energetic requirements which constrain a bubble in any RNA polymerases? T7 RNA polymerase is one of the simplest RNA polymerases and is the system for which we have the highest-resolution structural information. However, there is no high… CONTINUE READING
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Determinants of the stability of transcription elongation complexes: interactions of the nascent RNA with the DNA template and the RNA polymerase

  • K. S. Wilson, C. R. Conant, P. H. von Hippel
  • J Mol Biol
  • 1999
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