Fluorescence Lifetime Imaging of Endogenous Fluorophores in Histopathology Sections Reveals Differences Between Normal and Tumor Epithelium in Carcinoma In Situ of the Breast

@article{Conklin2009FluorescenceLI,
  title={Fluorescence Lifetime Imaging of Endogenous Fluorophores in Histopathology Sections Reveals Differences Between Normal and Tumor Epithelium in Carcinoma In Situ of the Breast},
  author={Matthew W. Conklin and Paolo P. Provenzano and Kevin W. Eliceiri and Ruth Sullivan and Patricia J. Keely},
  journal={Cell Biochemistry and Biophysics},
  year={2009},
  volume={53},
  pages={145-157}
}
The classical examination of histology slides from a mouse model of breast cancer has been extended in this study to incorporate modern multiphoton excitation and photon-counting techniques. The advantage of such approaches is quantification of potential diagnostic parameters from the fluorescence emission signal, whereby the traditional descriptive staging process is complemented by measurements of fluorescence intensity, lifetime, and spectra. We explored whether the clinical “gold standard… CONTINUE READING

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