Fluorescence In Situ Hybridization Analysis of t ( 3 ; 12 ) ( q 26 ; p 13 ) : A Recurring Chromosomal Abnormality

  • S . D . Raynaud, Baens, +9 authors Marynen
  • Published 2002

Abstract

We have identified a new recurrent reciprocal translocation between chromosome 3 and 12 with breakpoints at bands 3q26 and 12~13, t(3; 12)(q26;p13) in the malignant cells from five patients with acute transformation of myelodysplastic syndrome or blast crisis of chronic myelogenous leukemia. t(3;12)(q26;p13) appears as a rare but nonrandom event present in various myeloid leukemia subtypes,which is frequently associated with dysplasia of megakaryocytes, multilineage involvement, short duration of any blastic phase, and a very poor prognosis. Here, we report the molecular cytogenetic analysis of the t(3; 12). Fluorescence in situ hy-

Cite this paper

@inproceedings{Raynaud2002FluorescenceIS, title={Fluorescence In Situ Hybridization Analysis of t ( 3 ; 12 ) ( q 26 ; p 13 ) : A Recurring Chromosomal Abnormality}, author={S . D . Raynaud and Baens and Grosgeorge and Rodgers and C . D . L . Reid and M . Dainton and M E Dyer and J . G . Fuzibet and Gratecos and B . Taillan and Ayraud and Marynen}, year={2002} }