Fluorescence Correlation Spectroscopy: A Tool to Study Protein Oligomerization and Aggregation In Vitro and In Vivo.

@article{Sahoo2016FluorescenceCS,
  title={Fluorescence Correlation Spectroscopy: A Tool to Study Protein Oligomerization and Aggregation In Vitro and In Vivo.},
  author={Bankanidhi Sahoo and Kenneth W. Drombosky and Ronald Wetzel},
  journal={Methods in molecular biology},
  year={2016},
  volume={1345},
  pages={67-87}
}
Fluorescence correlation spectroscopy (FCS) is a highly sensitive analytical technique used to measure dynamic molecular parameters, such as diffusion time (from which particle size can be calculated), conformation, and concentration of fluorescent molecules. It has been particularly powerful in characterizing size distributions in molecular associations (e.g., dimer/multimer formation) both in well-behaved thermodynamically equilibrated systems in vitro as well as in more complex environments… CONTINUE READING
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