Fluorescein angiography and adverse drug reactions revisited: the Lions Eye experience

@article{Kwan2006FluoresceinAA,
  title={Fluorescein angiography and adverse drug reactions revisited: the Lions Eye experience},
  author={A. Kwan and C. Barry and I. McAllister and I. Constable},
  journal={Clinical \& Experimental Ophthalmology},
  year={2006},
  volume={34}
}
Background:  The last major survey of adverse reactions to intravenous fluorescein angiography was performed more than 20 years ago. There have been two recent fatalities involving intravenous fluorescein in Australia. It is important to review the current incidence of adverse reactions and latest literature on the pathogenesis, prophylaxis and alternatives to intravenous fluorescein angiography. 
Anaphylaxis with convulsions following intravenous fluorescein angiography at an outpatient clinic.
TLDR
Life threatening complications after intravenous injection of sodium fluorescein require immediate intervention and training for professionals are needed to standardize treatment for this event. Expand
The Fluorescent Patient: An Unusual Effect of Fluorescein Angiography
TLDR
The case of a 41-year-old patient with chronic ischemia caused by moyamoya syndrome who underwent bypass revascularization with intraoperative fluorescein angiography (FA) and immediately after the surgery, the patient presented homogeneous fluorescence of the entire skin. Expand
Allergy skin testing in predicting adverse reactions to fluorescein: a prospective clinical study
Purpose:  To evaluate allergy skin testing as a diagnostic tool of adverse reactions to fluorescein and whether allergy and previous sodium fluorescein angiography (SFA) act as predisposing factors.
Adverse reactions to fluorescein angiography: A comprehensive review of the literature.
TLDR
Pat characteristics including other comorbid diseases, allergy history, age, race, and gender showed only an increased rate of reaction in patients with a history of reaction to fluorescein, and the only proven method is reviewing allergy history. Expand
Fundamentals of Fluorescein Angiography.
TLDR
It is critical that ophthalmic team members understand the use of fluorescein for diagnosing eye-related diseases and conditions, including appropriate doses for adult and pediatric patients, as well as awareness of side effects, adverse reactions, and complications of the contrast agent. Expand
Risk factors for adverse reactions of fundus fluorescein angiography
TLDR
Fluorescein angiography is a safe procedure for patients who are relatively healthy but with a history of any systemic disease, but young age, prior reactions and motion sickness which are highly related to emetic events should be considered in the evaluation of ARs to fluoresceIn. Expand
Anaphylactic response to topical fluorescein 2% eye drops: a case report
TLDR
The case report of a 51-year-old woman who developed an anaphylactic reaction when she was administered fluorescein sodium 2% eye drops after cataract surgery is reported, revealing the potential for this benign eye drop to cause a life-threatening systemic reaction. Expand
A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment
A blunt trauma to a phthisical eye may elicit sympathetic ophthalmia. Non invasive imaging such as use of optical coherence tomography and angiography metrics of the retinal and choroidal vasculatureExpand
Slow versus Rapid Fluorescein Injection in Angiographic Studies for Retinal Vascular Disorders
TLDR
Slow fluorescein injection during fundusAngiography, instead of the usual rapid application, can be an effective way to reduce the incidence of nausea and vomiting in patients whose first phase of angiography is of little diagnostic importance. Expand
Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock
TLDR
This is, to the authors' knowledge, the first report where CD‐sens has been used to aid in diagnosing an IgE‐mediated anaphylactic shock caused by fluorescein. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Adverse reactions to fluorescein angiography
TLDR
Adverse reactions to ophthalmic patients during 9909 fluorescein angiographies during 9 years were registered, with nausea and vomiting being the most common untoward reactions. Expand
Adverse reactions in intravenous fluorescein angiography.
TLDR
No significant difference in the rate of adverse reactions was found when angiography using 10% fluorescein was compared with angiographies of the retina using 25% fluorscein. Expand
Adverse reaction to intravenous fluorescein: evidence for sex difference.
TLDR
Males react adversely more frequently than females to intravenous fluorescein angiography, as shown in a study of 547 patients, with no apparent cause for the increased frequency in the male cases. Expand
Adverse reaction to intravenous fluorescein: evidence for sex difference.
TLDR
Males react adversely more frequently than females to intravenous fluorescein angiography, as shown in a study of 547 patients, with no apparent cause for the increased frequency in the male cases found. Expand
Adverse reactions during intravenous fluorescein angiography.
TLDR
Intravenous (IV) fluorescein angiography has become a widely accepted diagnostic tool in ophthalmology since its description by Novatny and Alvis 1 in 1961 and nausea was the most common side effect, occurring in 6% of all patients. Expand
Low incidence of side effects following intravenous fluorescein angiography.
TLDR
Skin testing seems useless in attempting to predict allergic reactions in susceptible patients after fluorescein angiographies, as only one life-threatening situation, acute pulmonary edema, was found. Expand
Periorbital urticaria and topical fluorescein.
TLDR
A case of topical fluorescein-induced urticaria is described, described in this report, which is described as a routine component of the ophthalmic examination. Expand
Low incidence of side effects following intravenous fluorescein angiography.
TLDR
Skin testing seems useless in attempting to predict allergic reactions in susceptible patients after fluorescein angiographies, as only one life-threatening situation, acute pulmonary edema, was found. Expand
Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study.
TLDR
The authors found that the percentage of adverse reactions depended strongly on the patient's angiographic history, with patients who had had previous angiography without ever having had an adverse reaction significantly more likely to have had a reaction. Expand
SKIN NECROSIS FOLLOWING FLUORESCEIN EXTRAVASATION: A Survey of the Macula Society
TLDR
Although fluorescein angiography remains a safe procedure, efforts should be directed toward prevention of dye extravasation, and prompt and proper medical attention with close follow-up study may minimize the likelihood of skin necrosis. Expand
...
1
2
3
4
5
...