Fluoranthene-induced neurobehavioral toxicity in F-344 rats.

  title={Fluoranthene-induced neurobehavioral toxicity in F-344 rats.},
  author={Crystal R. Saunders and Dolores C. Shockley and Maurice E. Knuckles},
  journal={International journal of toxicology},
  volume={22 4},
Fluroanthene (FLA) is a nonalternant representative of polycyclic aromatic hydrocarbon (PAH) family of toxic chemicals that are widely distributed in the environment. The effects of single acute doses of FLA on locomotor activities and the functional observational battery (FOB) were investigated in 8-week-old male and female F-344 rats. FLA was dissolved in peanut oil and administered by oral gavage as single doses of 0, 100, 200 and 400 mg/kg. Immediately after dosing, animals were placed in… CONTINUE READING


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