FluoEM, virtual labeling of axons in three-dimensional electron microscopy data for long-range connectomics

  title={FluoEM, virtual labeling of axons in three-dimensional electron microscopy data for long-range connectomics},
  author={Florian Drawitsch and Ali Karimi and Kevin M. Boergens and Moritz Helmstaedter},
Volume electron microscopy (3D EM) has enabled the dense reconstruction of neuronal circuits in datasets that are so far about a few hundred micrometers in extent. In mammalian brains, most neuronal circuits are however highly non-local, such that a large fraction of the synapses in such a volume of neuropil originates from distant projection sources. The labeling and identification of such long-range axonal inputs from multiple sources within a densely reconstructed EM dataset has been… 

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