Flunarizine inhibits sensory neuron excitability by blocking voltage-gated Na+ and Ca2+ currents in trigeminal ganglion neurons.

Abstract

BACKGROUND Although flunarizine has been widely used for migraine prophylaxis with clear success, the mechanisms of its actions in migraine prophylaxis are not completely understood. The aim of this study was to investigate the effects of flunarizine on tetrodotoxin-resistant Na(+) channels and high-voltage activated Ca(2+) channels of acutely isolated… (More)

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Cite this paper

@article{Ye2011FlunarizineIS, title={Flunarizine inhibits sensory neuron excitability by blocking voltage-gated Na+ and Ca2+ currents in trigeminal ganglion neurons.}, author={Qing Ye and Qiang Wang and Lan-yun Yan and Wen-hui Wu and Sha Liu and Hang Xiao and Qi Wan}, journal={Chinese medical journal}, year={2011}, volume={124 17}, pages={2649-55} }