Flunarizine, a calcium influx blocker, inhibits TRH-but not potassium-stimulated prolactin secretion.


The effect of flunarizine on the secretion of prolactin from monolayer cultures of normal rat pituitary cells has been determined. Both basal and TRH-stimulated secretion were found to be significantly inhibited by micromolar concentrations of flunarizine, whereas depolarization (high K+)-stimulated secretion was virtually unaffected. These results indicate… (More)


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