Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure

@article{Mintzer2004FlumazenilprecipitatedWI,
  title={Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure},
  author={M. Mintzer and R. Griffiths},
  journal={Psychopharmacology},
  year={2004},
  volume={178},
  pages={259-267}
}
RationaleParametric preclinical studies of the benzodiazepine antagonist flumazenil have contributed to the understanding of the physical dependence associated with chronic benzodiazepine use. However, few parametric studies have been conducted in human participants.ObjectiveThis study was designed to assess the effect of duration of benzodiazepine exposure on the intensity of flumazenil-precipitated withdrawal in healthy volunteers.MethodParticipants were randomly assigned to receive either… Expand
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