Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice

@article{Belzung2000FlumazenilIB,
  title={Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice},
  author={Catherine Belzung and A. M. Le Guisquet and F. Crestani},
  journal={Psychopharmacology},
  year={2000},
  volume={148},
  pages={24-32}
}
Rationale: Some anxiety disorders may be treated in a different way than normal anxiety. Objective: This study was aimed at investigating the action of the benzodiazepine receptor antagonist flumazenil, compared to that of the benzodiazepine receptor full agonist chlordiazepoxide, in an animal model of generalised anxiety disorder (the BALB/c mouse). Methods: Flumazenil (0.0001, 0.001, 0.01, 0.1 and 1 mg/kg) or chlordiazepoxide (5 mg/kg) were administered to BALB/c or C57BL/6 mice subjected to… CONTINUE READING
20 Citations
85 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 85 references

Blockade of anxiolytic - like actions of chlordiazepoxide by naloxone in the elevated plus - maze : comparisons between Swiss , C 57 BL / 6 and BALB / c mice

  • A Ågmo, C Belzung, X Deloire, M Grassin, S Lewis
  • Psychobiology
  • 1999

Function of GABAA - receptor subtypes : mice with point - mutated diazepam - insensitive GABAA α 1 - receptors

  • U Rudolf, F Crestani, +7 authors H Mohler
  • Soc Neurosci Abstr
  • 1998

Similar Papers

Loading similar papers…