Flumazenil in the management of acute drug overdosage with benzodiazepines and other agents.

@article{OSullivan1987FlumazenilIT,
  title={Flumazenil in the management of acute drug overdosage with benzodiazepines and other agents.},
  author={G. O'Sullivan and Denis N. Wade},
  journal={Clinical pharmacology and therapeutics},
  year={1987},
  volume={42 3},
  pages={254-9}
}
A double-blind, randomized, placebo-controlled trial was employed to evaluate the place of flumazenil, a benzodiazepine antagonist, in the early management of 60 patients who went to an accident and emergency center with overdosage of sedatives. The level of consciousness was monitored by a modified Glasgow Coma Scale, and the response to the intravenous administration of up to 1 mg flumazenil or placebo was followed for periods between 1 and 24 hours. The increases in the glasgow coma scale at… CONTINUE READING