Flumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam.

@article{Flaishon2003FlumazenilAD,
  title={Flumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam.},
  author={Ron Flaishon and Avi A. Weinbroum and Leo Veenman and Svetlana Leschiner and Valerie Rudick and Moshe Gavish},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={97 4},
  pages={1046-52, table of contents}
}
UNLABELLED In an effort to clarify the mechanism of action of isoflurane, we studied the effect of flumazenil on mice chronically treated with isoflurane or diazepam. Mice were pretreated with diazepam, isoflurane, or saline, with and without flumazenil. After 2 wk, responses to isoflurane and diazepam were assessed, and central benzodiazepine receptor (CBR) binding characteristics were assayed. Mice pretreated with isoflurane failed the horizontal wire test at a larger isoflurane concentration… CONTINUE READING
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